Definition

A rare, inherited disorder in which many fast-growing tumors that look like squamous cell skin cancer form on the nose, face, ears, arms, and legs. The tumors usually go away on their own, but often leave deep, pitted scars in the skin. The tumors on the arms and legs are often larger and leave flat scars. Ferguson-Smith syndrome is caused by mutations (changes) in the TGFBR1 gene. Also called MSSE and multiple self-healing squamous epithelioma.