Single Biggest Cancer Dictionary in the World
What is
KRAS G12C inhibitor BPI-421286
?Pronunciation: /kræs ʤi twɛlv si ˌɪnˈhɪbətər bpi* fɔr ˈhənərd ənd tˈwɛntiˌwɔn ˈθaʊzənd, tu ˈhənərd ənd eighty-six*/
KRAS G12C inhibitor BPI-421286
Definition
An orally bioavailable inhibitor of the oncogenic KRAS substitution mutation G12C, with potential antineoplastic activity. Upon oral administration, KRAS G12C inhibitor BPI-421286 selectively targets the KRAS G12C mutant and inhibits KRAS G12C-mediated signaling. This may halt proliferation and metastasis in susceptible tumor cells. KRAS, a member of the RAS family of oncogenes, serves an important role in cell signaling, division and differentiation. Mutations of KRAS may induce constitutive signal transduction leading to tumor cell proliferation, invasion, and metastasis.