Single Biggest Cancer Dictionary in the World
What is HER2-targeting antibody Fc fragment FS102?
Pronunciation: /hər tu ˈtɑrgətɪŋ ˈæntɪˌbɑdi fc* ˈfrægmənt fs* wən ˈhənərd ənd tu/
HER2-targeting antibody Fc fragment FS102
Definition
A proprietary, antibody fragment composed of a constant (Fc) region that is engineered to bind to the tumor-associated antigen human epidermal growth factor receptor-2 (HER2), with potential antineoplastic activity. HER2-targeted antibody Fc fragment FS102 specifically binds to its HER2 epitope, and causes downregulation of HER2-mediated signaling. This leads to tumor cell apoptosis. HER2, a member of the receptor tyrosine kinase (RTK) epidermal growth factor receptor (EGFR) superfamily, is overexpressed on the cell surface of various solid tumors.