Single Biggest Cancer Dictionary in the World
What is thorium Th 227 anti-HER2 monoclonal antibody BAY2701439?
Pronunciation: /ˈθɑriəm ˈtiˈeɪʧ tu ˈhənərd ənd twenty-seven* ˈænˌti hər tu ˌmɑnəˈkloʊnəl ˈæntɪˌbɑdi beɪ tu ˈmɪljən, ˈsɛvən ˈhənərd ənd wən ˈθaʊzənd, fɔr ˈhənərd ənd thirty-nine*/
thorium Th 227 anti-HER2 monoclonal antibody BAY2701439
Definition
A radioimmunoconjugate consisting of a monoclonal antibody targeting the tyrosine kinase receptor epidermal growth factor receptor 2 (HER2; ErbB2) and labeled with the alpha-emitting radioisotope thorium Th 227, with potential antineoplastic activity. Upon administration, the monoclonal antibody moiety of BAY2701439 targets and specifically binds to HER2 on tumor cells, delivering a cytotoxic dose of alpha radiation to cells expressing HER2. HER2 is overexpressed in a variety of cancer cell types and is associated with increased tumor cell proliferation.