Definition

An imaging agent containing a plectin-1 (Plec1; plectin) targeting peptide (PTP), with potential use for the detection of Plec1-expressing tumor cells using single-photon emission computed tomography (SPECT). Upon administration, the Plec1 targeting agent PTP-01 specifically targets and binds to Plec1 on Plec1-expressing cancer cells. Upon SPECT imaging, the Plec1-expressing cancer cells can be visualized. Plec1, a pro-tumorigenic protein, is normally found inside the cytoplasm of healthy cells but is only selectively expressed on the cell surface of various cancer cells and plays an important role in cancer cell proliferation, migration and invasion.