Single Biggest Cancer Dictionary in the World
What is PIM kinase inhibitor TP-3654?
Pronunciation: /pim* kinase* ˌɪnˈhɪbətər tp* θri ˈθaʊzənd, sɪks ˈhənərd ənd fifty-four*/
PIM kinase inhibitor TP-3654
Definition
An orally available, second-generation and selective ATP-competitive inhibitor of proviral integration site for Moloney murine leukemia virus (PIM) kinases, with potential antineoplastic activity. Upon oral administration, PIM kinase inhibitor TP-3654 selectively binds to and prevents the activation of the PIM kinases. This prevents the activation of PIM-mediated signaling pathways and inhibits proliferation in cells that overexpress PIM. PIMs, constitutively active proto-oncogenic serine/threonine kinases, are upregulated in various types of cancers and play key roles in tumor cell proliferation and survival.