Single Biggest Cancer Dictionary in the World
What is PI3K/mTOR kinase inhibitor PF-04691502?
Pronunciation: /paɪ θri keɪ mtor* kinase* ˌɪnˈhɪbətər pf* fɔr ˈmɪljən, sɪks ˈhənərd ənd ninety-one* ˈθaʊzənd, faɪv ˈhənərd ənd tu/
PI3K/mTOR kinase inhibitor PF-04691502
Definition
An agent targeting the phosphatidylinositol 3 kinase (PI3K) and mammalian target of rapamycin (mTOR) in the PI3K/mTOR signaling pathway, with potential antineoplastic activity. PI3K/mTOR kinase inhibitor PF-04691502 inhibits both PI3K and mTOR kinases, which may result in apoptosis and growth inhibition of cancer cells overexpressing PI3K/mTOR. Activation of the PI3K/mTOR pathway promotes cell growth, survival, and resistance to chemotherapy and radiotherapy; mTOR, a serine/threonine kinase downstream of PI3K, may also be activated independent of PI3K.