Single Biggest Cancer Dictionary in the World
What is
KRAS G12C inhibitor HBI-2438
?Pronunciation: /kræs ʤi twɛlv si ˌɪnˈhɪbətər hbi* tu ˈθaʊzənd, fɔr ˈhənərd ənd thirty-eight*/
KRAS G12C inhibitor HBI-2438
Definition
An orally bioavailable inhibitor of the oncogenic KRAS substitution mutation G12C, with potential antineoplastic activity. Upon oral administration, KRAS G12C inhibitor HBI-2438 selectively targets the KRAS G12C mutant and inhibits KRAS G12C-mediated signaling. This may halt proliferation and metastasis in susceptible tumor cells. KRAS, a member of the RAS family of oncogenes, serves an important role in cell signaling, division and differentiation. Mutations of KRAS may induce constitutive signal transduction leading to tumor cell proliferation, invasion, and metastasis.