Definition

A radioconjugate composed of ICAM-1pep, an intercellular adhesion molecule-1 (ICAM-1; CD54)-targeted tracer, labeled with the radioisotope gallium Ga 68, with potential use as a tracer for ICAM-1 during positron emission tomography/computed tomography (PET/CT). Upon administration of gallium Ga 68-ICAM-1pep, the ICAM-1pep moiety targets and binds to ICAM-1. Upon binding, ICAM-1pep expression can be detected during PET/CT imaging. ICAM-1, an inducible glycoprotein of the immunoglobulin superfamily (IgSF) normally expressed on leukocytes and endothelial cells, may be overexpressed in a variety of cancers. Its expression may also be up-regulated in nonirradiated tumors that are responsive to radiation therapy.