Definition

A radioconjugate composed of two human prostate-specific membrane antigen (PSMA)-binding motifs linked to a sarcophagine (SAR)-based chelator and radiolabeled with the beta-emitting radioisotope copper Cu 67, with potential antineoplastic activity. Upon administration of copper Cu 67 SAR-bisPSMA, the PSMA-binding motifs target and bind to PSMA-expressing tumor cells, thereby delivering a cytotoxic dose of beta radiation to PSMA-expressing tumor cells. PSMA, a tumor-associated antigen (TAA) and type II transmembrane protein, is expressed on the membrane of prostatic epithelial cells and overexpressed on prostate tumor cells as well as a variety of other solid tumors.