Definition

A cell-based cancer vaccine composed of autologous dendritic cells (DCs) pulsed with ovarian cancer-specific antigen(s), with potential immunostimulatory and antineoplastic activities. Upon subcutaneous administration of the autologous ovarian cancer-specific antigens-pulsed DCs Cellgram-DC near the lymph nodes, the DCs stimulate a specific cytotoxic T-lymphocyte (CTL)-mediated immune response against the ovarian cancer cells expressing the antigens, resulting in tumor cell lysis.