Definition

A recombinant protein consisting of an antigen-binding fragment (Fab) of CSR02, a monoclonal antibody directed against plasmalemma vesicle associated protein (PLVAP), and linked to human tissue factor (TF), with potential antineoplastic activity. Upon intra-arterial (IA) infusion of CSR02-Fab-TF, the Fab moiety targets and binds to the vascular endothelial cell specific protein PLVAP that is present on the blood vessels of hepatocellular carcinoma (HCC) but that is not present on the blood vessels of normal liver tissue. In turn, TF initiates the clotting cascade, thereby blocking blood supply from the hepatic artery to the HCC. This deprives the HCC of its blood supply and leads to tumor cell death.