Single Biggest Cancer Dictionary in the World
What is androgen receptor degrader RO7656594?
Pronunciation: /androgen* riˈsɛptər degrader* roʊ ˈsɛvən ˈmɪljən, sɪks ˈhənərd ənd fifty-six* ˈθaʊzənd, faɪv ˈhənərd ənd ninety-four*/
androgen receptor degrader RO7656594
Definition
An orally bioavailable androgen receptor (AR) degrader, with potential antineoplastic activity. Upon oral administration, AR degrader RO7656594 targets, binds to and degrades AR, thereby preventing AR-mediated signaling and inhibiting the proliferation of AR-overexpressing tumor cells. AR, a hormone-regulated transcription factor, plays a key role in tumor cell proliferation in castration-resistant prostate cancer (CRPC).