Single Biggest Cancer Dictionary in the World
What is yttrium Y 90 anti-CD45 monoclonal antibody BC8?
Pronunciation: /ˈɪtriəm waɪ ˈnaɪnti ˈænˌti ˈsiˈdi ˈfɔrtiˌfaɪv ˌmɑnəˈkloʊnəl ˈæntɪˌbɑdi bc* eɪt/
yttrium Y 90 anti-CD45 monoclonal antibody BC8
Definition
A radioimmunoconjugate containing the murine IgG1 anti-CD45 monoclonal antibody (MoAb) BC8 labeled with yttrium 90 (Y90), with potential immunotherapeutic activity. Yttrium Y 90 anti-CD45 monoclonal antibody BC8 binds to CD45 antigen, a receptor protein-tyrosine phosphatase expressed on the surface of both normal and malignant hematopoietic cells. After binding and internalization by CD45-expressing tumor cells, this agent may deliver a cytotoxic dose of beta radiation.