Single Biggest Cancer Dictionary in the World
What is selective estrogen receptor degrader AZD9496?
Pronunciation: /səˈlɛktɪv ˈɛstrəʤən riˈsɛptər degrader* azd* naɪn ˈθaʊzənd, fɔr ˈhənərd ənd ninety-six*/
selective estrogen receptor degrader AZD9496
Definition
An orally available selective estrogen receptor degrader (SERD), with potential antineoplastic activity. Upon administration, SERD AZD9496 binds to the estrogen receptor (ER) and induces a conformational change that results in the degradation of the receptor. This prevents ER-mediated signaling and inhibits the growth and survival of ER-expressing cancer cells.