Definition

A drug used alone to treat adults with HER2-negative breast cancer that has spread and has certain mutations (changes) in the BRCA1 or BRCA2 gene and with enzalutamide to treat adults with prostate cancer that has spread, has not responded to treatments that lower testosterone levels, and has a mutation in the HRR gene. It is also being studied in the treatment of other types of cancer. Talazoparib tosylate blocks an enzyme involved in many cell functions, including the repair of DNA damage. Blocking this enzyme may help keep cancer cells from repairing their damaged DNA, causing them to die. Talazoparib tosylate is a type of PARP inhibitor. Also called Talzenna.