Definition

A gene that is part of a cell signaling pathway involved in the formation of tissues and organs, cell growth, and cell division during embryonic development. Mutations (changes) in the SUFU gene may cause cells to grow and divide too quickly or in an uncontrolled way. This may cause abnormal cells, including cancer cells, to grow. SUFU gene mutations have been found in an inherited condition called basal cell nevus syndrome and in a type of brain cancer called medulloblastoma. The SUFU gene is a type of tumor suppressor gene.