Definition

Stage 4 neuroblastoma is divided into stages 4 and 4S. In stage 4, the cancer has spread to distant lymph nodes or to other parts of the body. In stage 4S, the child is younger than 12 months, and (1) the cancer has spread to the skin, liver, and/or bone marrow; or (2) the cancer is in only one area and all of the cancer that can be seen may or may not be completely removed during surgery; or (3) cancer cells may be found in the lymph nodes near the tumor.