Definition

A drug used to treat adults with desmoid tumors (a type of soft tissue tumor) that have gotten worse and need systemic therapy. It is also being studied in the treatment of other types of cancer. Nirogacestat hydrobromide binds to a protein called gamma secretase, which blocks the activation of other proteins called Notch receptors. Blocking these proteins may help keep tumor cells from growing and may kill them. Nirogacestat hydrobromide is a type of gamma secretase inhibitor. Also called Ogsiveo.