Definition

A drug used alone or with other drugs to treat adults with certain types of acute myeloid leukemia, cholangiocarcinoma (a type of bile duct cancer), or myelodysplastic syndromes that have a mutation (change) in the IDH1 gene. It is also being studied in the treatment of other types of cancer. Ivosidenib blocks the protein made by the mutated IDH1 gene, which may help keep cancer cells from growing. It is a type of enzyme inhibitor and a type of targeted therapy. Also called Tibsovo.