Definition

A drug used to treat postmenopausal women and adult men with estrogen receptor-positive, HER2-negative breast cancer that has a mutation (change) in the ESR1 gene and is advanced or has spread to other parts of the body. It is used in patients whose disease got worse after treatment with at least one type of hormone therapy. Elacestrant dihydrochloride binds to proteins called estrogen receptors, which are found on some breast cancer cells. These proteins may cause cancer cells to grow. Elacestrant dihydrochloride blocks these proteins and may keep cancer cells from growing. It is a type of estrogen receptor antagonist. Also called Orserdu.