Definition

A drug that binds to the protein vascular endothelial growth factor (VEGF) to help keep new blood vessels from forming and is used to treat different types of cancer. It is used alone or with other drugs to treat certain types of non-small cell lung cancer, hepatocellular carcinoma (a type of liver cancer), colorectal cancer, stomach cancer, and gastroesophageal junction cancer. It is also being studied in the treatment of other types of cancer. Anti-VEGFR-2 fully human monoclonal antibody IMC-1121B may prevent the growth of new blood vessels that tumors need to grow. It is a type of antiangiogenesis agent and a type of monoclonal antibody. Also called Cyramza, IMC-1121B, and ramucirumab.