Single Biggest Cancer Dictionary in the World
What is
sodium phenylbutyrate
?Pronunciation: /ˈsoʊdiəm phenylbutyrate*/
sodium phenylbutyrate
Definition
The sodium salt of phenylbutyrate, a derivative of the short-chain fatty acid butyrate, with potential antineoplastic activity. Phenylbutyrate reversibly inhibits class I and II histone deacetylases (HDACs), which may result in a global increase in gene expression, decreased cellular proliferation, increased cell differentiation, and the induction of apoptosis in susceptible tumor cell populations.