Single Biggest Cancer Dictionary in the World
What is SLFN12-PDE3A complex inducer BAY 2666605?
Pronunciation: /slfn* twɛlv pde* θri ə ˈkɑmplɛks inducer* beɪ tu ˈmɪljən, sɪks ˈhənərd ənd sixty-six* ˈθaʊzənd, sɪks ˈhənərd ənd faɪv/
SLFN12-PDE3A complex inducer BAY 2666605
Definition
An orally bioavailable agent that triggers the formation of a complex of the two proteins Schlafen family member 12 (SLFN12) and phosphodiesterase 3A (PDE3A), with potential antineoplastic activity. Upon oral administration, SLFN12-PDE3A complex inducer BAY2666605 triggers the formation of the SLFN12-PDE3A complex. This stabilizes SLFN12 and alters the expression of a set of genes that regulate cell survival, death, and proliferation. This suppresses cell cycle progression and induces apoptosis in cancer cells that specifically express elevated levels of both of these proteins.