Definition

A population of allogeneic related donor cytotoxic T lymphocytes (CTLs) specifically reactive to human adenovirus (Ad) with potential immunomodulating and anti-adenoviral activities. Upon infusion of related donor Ad-specific CTLs, these cells help reconstitute Ad-specific CTL responses in patients at risk of developing Ad infections after allogeneic stem cell transplant or in Ad-infected immunocompromised hosts. These related donor Ad-specific CTLs are manufactured with the CliniMACS Prodigy Cytokine Capture System which facilitates production of the Ad-specific CTLs.