Single Biggest Cancer Dictionary in the World
What is pyrazofurin?
Pronunciation: /pyrazofurin*/
pyrazofurin
Definition
A nucleoside analog. Pyrazofurin potently inhibits orotidine 5′-monophosphate (OMP) decarboxylase, thereby interfering with de novo synthesis of uridine nucleotides and resulting in cytotoxicity. This agent also causes a rapid depletion of the pyrimidine deoxynucleotide pool, thereby inhibiting DNA synthesis and cell replication.