Definition

A preparation of soluble adapter molecules consisting of an antigen-binding moiety targeting the tumor-associated antigen (TAA) human prostate-specific membrane antigen (PSMA), linked to a peptide motif recognizable by UniCAR02-T, that may be used to activate UniCAR02-T. Upon administration of PSMA-specific targeting module (TM) TMpPSMA, and upon co-administration of UniCAR02-T, the antigen-binding moiety of TMpPSMA targets and binds to cancer cells expressing PSMA, and the binding domain of UniCAR02-T binds to the nuclear antigen motif of TMpPSMA. This activates UniCAR02-T, and induces selective toxicity in and causes lysis of PSMA-expressing tumor cells. PSMA is overexpressed on the surface of metastatic and hormone-refractory prostate cancer cells.