Single Biggest Cancer Dictionary in the World
What is prostaglandin E2 EP4 receptor inhibitor AN0025?
Pronunciation: /proʊstæˈglændɪn i tu ep* fɔr riˈsɛptər ˌɪnˈhɪbətər ən tˈwɛntiˌfaɪv/
prostaglandin E2 EP4 receptor inhibitor AN0025
Definition
An orally bioavailable antagonist of the prostaglandin E2 (PGE2) receptor type 4 (EP4; EP-4), with potential immunomodulating and antineoplastic activities. Upon oral administration, AN0025 selectively targets, binds to and blocks the activity of immunosuppressive tumor-associated myeloid cells (TAMCs) in the microenvironment. This abolishes TAMC-dependent immunosuppression and reduces tumor cell proliferation. The presence of immunosuppressive myeloid cells in certain tumors is associated with a poor prognosis.