Definition

A dietary powder supplement consisting of a mixture of various, as of yet not fully elucidated, berries, with potential antineoplastic and anti-angiogenic activities. As berries are rich in phytonutrients, such as anthocyanins, flavonols, ellagitannins, galltannins, proanthocyanidins, and phenolic acids, the antineoplastic effects of the powdered mixed berry extract supplement on cancer cells may be attributable to the phytonutrients’ antioxidant and pro-apoptotic activities. Upon administration of the powdered mixed berry extract supplement, the phytochemicals in the berries may work together to reduce angiogenesis, tumor growth and tumor development. Specifically, various phytochemicals may inhibit the multidrug resistance protein-1 (MRP-1), which results in the accumulation of cellular oxidized glutathione (GSSG). Elevated intracellular levels of GSSG causes an increase in oxidative stress. This triggers the induction of oxidative stress-mediated apoptosis and may inhibit tumor and endothelial cell proliferation. MRP-1, overexpressed in many different types of cancer, plays a key role in the efflux of GSSG and thus the maintenance of oxidative homeostasis and survival in tumor cells.