Single Biggest Cancer Dictionary in the World

What is

porcupine inhibitor RXC004

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Pronunciation: /ˈpɔrkjəˌpaɪn ˌɪnˈhɪbətər rxc* fɔr/

porcupine inhibitor RXC004

Definition

An orally available inhibitor of porcupine (PORCN), with potential antineoplastic activity. Upon oral administration, RXC004 binds to and inhibits PORCN in the endoplasmic reticulum (ER), which blocks post-translational acylation of Wnt ligands and inhibits their secretion. This prevents the activation of Wnt ligands, interferes with Wnt-mediated signaling, and inhibits cell growth in Wnt-driven tumors. Porcupine, a membrane-bound O-acyltransferase (MBOAT), is required for the palmitoylation of Wnt ligands, and plays a key role in Wnt ligand secretion and activity. Wnt signaling is dysregulated in a variety of cancers.