Single Biggest Cancer Dictionary in the World
What is Polo-like kinase 1 inhibitor NMS-1286937?
Pronunciation: /ˈpoʊloʊ laɪk kinase* wən ˌɪnˈhɪbətər nms* wən ˈmɪljən, tu ˈhənərd ənd eighty-six* ˈθaʊzənd, naɪn ˈhənərd ənd thirty-seven*/
Polo-like kinase 1 inhibitor NMS-1286937
Definition
An orally bioavailable, small-molecule Polo-like kinase 1 (PLK1) inhibitor with potential antineoplastic activity. Polo-like kinase 1 inhibitor NMS-1286937 selectively inhibits PLK1, inducing selective G2/M cell-cycle arrest followed by apoptosis in a variety of tumor cells while causing reversible cell-cycle arrest at the G1 and G2 stages without apoptosis in normal cells. PLK1 inhibition may result in the inhibition of proliferation in PLK1-overexpressing tumor cells. PLK1 is a serine/threonine protein kinase crucial in the regulation of mitosis.