Single Biggest Cancer Dictionary in the World
What is PNP-expressing ovine atadenovirus FP253?
Pronunciation: /pnp* ɪkˈsprɛsɪŋ ovine* atadenovirus* fp* tu ˈhənərd ənd fifty-three*/
PNP-expressing ovine atadenovirus FP253
Definition
An ovine atadenovirus encoding E. coli purine nucleoside phosphorylase (PNP) with prodrug activating activity. Under the control of a prostate-directed promoter, PNP-expressing atadenovirus vaccine FP253 expresses PNP in prostate tissue only after intraprostatic administration; this enzyme catalyzes systemically administered fludarabine prodrug into the active agent, 2-fluoroadenine. Localized prodrug activation provides prostate-targeted chemotherapy, potentially reducing systemic side effects.