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What is personalized neoantigen plasmid DNA melanoma vaccine EVX-02?
Pronunciation: /ˈpərsənəˌlaɪzd neoantigen* plasmid* ˈdiˌɛˈneɪ ˌmɛləˈnoʊmə ˌvækˈsin evx* tu/
personalized neoantigen plasmid DNA melanoma vaccine EVX-02
Definition
A plasmid DNA melanoma vaccine composed of DNA plasmid encoding multiple, melanoma patient-specific neoepitopes, which are highly immunogenic tumor associated antigens (TAAs), with potential immunostimulatory and antineoplastic activities. Upon intramuscular (IM) administration of personalized neoantigen plasmid DNA melanoma vaccine EVX-02, the plasmid DNA is taken up by antigen-presenting cells (APCs) and the expressed neoepitopes induce cytotoxic T-lymphocyte (CTL)-mediated immune responses against melanoma cells expressing these specific TAAs.