Single Biggest Cancer Dictionary in the World
What is pan-PI3K inhibitor CLR457?
Pronunciation: /pæn paɪ θri keɪ ˌɪnˈhɪbətər clr* fɔr ˈhənərd ənd fifty-seven*/
pan-PI3K inhibitor CLR457
Definition
An orally bioavailable pan inhibitor of phosphatidylinositol-3-kinase (PI3K), with potential antineoplastic activity. Upon oral administration, pan-PI3K inhibitor CLR457 inhibits all of the PI3K kinase isoforms, which may result in apoptosis and growth inhibition in tumor cells overexpressing PI3K. Activation of the PI3K pathway promotes cell growth, survival, and resistance to both chemotherapy and radiotherapy.