Single Biggest Cancer Dictionary in the World
What is P-cadherin-targeting agent PF-06671008?
Pronunciation: /pi cadherin* ˈtɑrgətɪŋ ˈeɪʤənt pf* sɪks ˈmɪljən, sɪks ˈhənərd ənd seventy-one* ˈθaʊzənd ənd eɪt/
P-cadherin-targeting agent PF-06671008
Definition
An agent that targets p-cadherin (CDH3), with potential antineoplastic activity. Upon administration, PF-06671008 binds to and inhibits the activity of p-cadherin; this may inhibit both invasion and proliferation of p-cadherin-expressing tumor cells. P-cadherin, a cell-surface protein and member of the cadherin family, is overexpressed in a variety of tumors and plays a role in cell adhesion, motility, invasion, and proliferation.