Single Biggest Cancer Dictionary in the World
What is
nucleoside analog DFP-10917
?Pronunciation: /nucleoside* ˈænəˌlɔg dfp* tɛn ˈθaʊzənd, naɪn ˈhənərd ənd ˈsɛvənˈtin/
nucleoside analog DFP-10917
Definition
A deoxycytosine analog with potential antineoplastic activity. Upon administration, DFP-10917 is phosphorylated to generate its nucleotide form, which functions as a deoxycytosine mimic and is incorporated into DNA in tumor cells. This causes DNA strand breaks during polymerization due to beta-elimination during the fidelity checkpoint, which results in G2/M phase-arrest and tumor cell apoptosis.