Single Biggest Cancer Dictionary in the World
What is
NLRP3 agonist BMS-986299
?Pronunciation: /nlrp* θri ˈægənɪst bms* naɪn ˈhənərd ənd eighty-six* ˈθaʊzənd, tu ˈhənərd ənd ninety-nine*/
NLRP3 agonist BMS-986299
Definition
A nucleotide-binding domain and leucine-rich repeat (NLR) family pyrin domain containing 3 (NLRP3; NACHT, LRR and PYD Containing Protein 3; NALP3) agonist with potential immunomodulatory and antineoplastic activities. Upon administration, NLRP3 agonist BMS-986299 binds to and activates NLRP3, potentially promoting NLRP3 inflammasome-mediated secretion of interleukin-8 (IL-8), which may induce tumoricidal activity of natural killer (NK) cells against tumor cells. NLRP3, a sensor component of the NLRP3 inflammasome plays a significant role in immunity and inflammation, and may protect against tumorigenesis in some cancers.