Single Biggest Cancer Dictionary in the World

What is

neoantigen DNA-based pancreatic cancer vaccine

?

Pronunciation: /neoantigen* ˈdiˌɛˈneɪ beɪst ˌpænkriˈætɪk ˈkænsər ˌvækˈsin/

neoantigen DNA-based pancreatic cancer vaccine

Definition

A personalized, polyepitope DNA vaccine composed of a DNA plasmid encoding multiple, highly immunogenic tumor associated antigens (TAAs) that are specifically expressed by a patient’s pancreatic cancer cells, including personalized epitopes of the TAA mesothelin, with potential immunostimulatory and antineoplastic activities. Upon intramuscular administration and electroporation of the neoantigen DNA-based pancreatic cancer vaccine, the expressed TAAs induce a specific cytotoxic T-lymphocyte (CTL) immune response against tumor cells expressing the neoantigens.