Definition

A near-infrared (NIR) fluorescent imaging agent and cyanine dye targeting urine proteins, that can potentially be used to improve visualization of the ureter during NIR fluorescence imaging-guided surgery. Upon intravenous administration, NIR imaging agent IS-001 targets and binds to urine proteins in the ureter. Upon fluorescent imaging, the ureter can be visualized and identified. This may prevent ureter injury during pelvic and abdominal surgeries.