Definition

A synthetic double-stranded RNA (dsRNA) polyinosinic:polycytidylic acid (poly I:C) nanoplexed with the cationic carrier polyethylenimine (PEI), with potential immunostimulating and antineoplastic activities. Upon intratumoral administration, nanoplexed poly I:C BO-112, which mimics viral RNAs, may stimulate the release of cytotoxic cytokines and induces interferon-gamma production. This may increase the tumoricidal activities of various immunohematopoietic cells. The PEI carrier enhances the delivery of the agent into the cells.