Definition

A marine-derived tubulin destablizer, with antineoplastic and antiangiogenic activities. Upon administration, microtubule destabilizer PM534 targets and binds to beta-tubulin at the colchicine site and thereby destabilizes the microtubular network in the tumor cell, which inhibits the polymerization of microtubules and leads to cell cycle arrest, blockage of cell division and an induction of cell death in cancer cells. In addition, PM534 is a potent inhibitor of angiogenesis, which prevents the formation of blood vessels necessary for tumor growth.