Single Biggest Cancer Dictionary in the World
What is
Met tyrosine kinase inhibitor BMS-777607
?Pronunciation: /mɛt tyrosine* kinase* ˌɪnˈhɪbətər bms* ˈsɛvən ˈhənərd ənd seventy-seven* ˈθaʊzənd, sɪks ˈhənərd ənd ˈsɛvən/
Met tyrosine kinase inhibitor BMS-777607
Definition
An inhibitor of MET tyrosine kinase with potential antineoplastic activity. MET tyrosine kinase inhibitor BMS-777607 binds to c-Met protein, or hepatocyte growth factor receptor (HGFR), preventing binding of hepatocyte growth factor (HGF) and disrupting the MET signaling pathway; this agent may induce cell death in tumor cells expressing c-Met. c-Met, a receptor tyrosine kinase overexpressed or mutated in many tumor cell types, plays an important role in tumor cell proliferation, survival, invasion, and metastasis, and in tumor angiogenesis.