Single Biggest Cancer Dictionary in the World

What is

lutetium Lu 177 PSMA-10.1

?

Pronunciation: /lutetium* lu wən ˈhənərd ənd seventy-seven* psma* tɛn wən/

lutetium Lu 177 PSMA-10.1

Definition

A radioconjugate composed of PSMA-10.1, a prostate-specific membrane antigen (PSMA)-targeting ligand and radiolabeled with the beta-emitting radioisotope lutetium Lu 177 (177Lu), with potential antineoplastic activity against PSMA-expressing tumor cells. Upon intravenous administration of lutetium Lu 177 PSMA-10.1, PSMA-10.1 targets and binds to PSMA-expressing tumor cells. Upon binding, PSMA-expressing tumor cells are destroyed by 177Lu through the specific delivery of beta particle radiation. PSMA, a tumor-associated antigen (TAA) and type II transmembrane protein, is expressed on the membrane of prostatic epithelial cells and overexpressed on prostate tumor cells as well as a variety of other solid tumors.