Definition

A preparation of allogeneic mesenchymal stem cells (MSCs) derived from induced pluripotent stem cells (iPSCs), with potential immunomodulating activity. iPSCs are derived from one healthy adult donor and are expanded and differentiated into mesenchymoangioblasts (MCAs), which are further expanded and cultured, upon which MSCs are formed and further expanded. Upon intravenous administration and following allogeneic hematopoietic stem cell transplantation (HSCT), the iPSC-derived MSCs CYP-001 may attenuate and prevent acute graft versus host disease (aGvHD).