Single Biggest Cancer Dictionary in the World
What is interleukin-15/interleukin-15 receptor alpha complex-Fc fusion protein XmAb24306?
Pronunciation: /ˌɪntərˈlukɪn ˈfɪfˈtin ˌɪntərˈlukɪn ˈfɪfˈtin riˈsɛptər ˈælfə ˈkɑmplɛks fc* fˈjuʒən ˈproʊˌtin xmab* tˈwɛntiˌfɔr ˈθaʊzənd, θri ˈhənərd ənd sɪks/
interleukin-15/interleukin-15 receptor alpha complex-Fc fusion protein XmAb24306
Definition
An interleukin (IL)-15/IL-15-receptor alpha (IL-15Ra) complex fused to a bispecific Fc domain, with potential antineoplastic activity. Upon administration, XmAb24306 stimulates the proliferation of natural killer (NK) cells and memory CD8+ T cells. The memory T cells enhance the secretion of the cytokine interferon-gamma (IFN-g), which further potentiates the immune response against tumor cells. This may increase tumor cell killing and decrease tumor cell proliferation. IL-15 regulates CD8+ T and NK cell development, activation and proliferation. XmAb24306 does not require endogenous IL-15Ra for its activation.