Definition

An allograft composed of sterile, decellularized regenerative human dermal tissue matrix, with soft tissue reconstructive and transplantation purposes. In this human acellular dermal matrix (hADM), which is composed of the dermal layer and extracellular matrix of thin layers of donated skin that have had the epidermal layer removed, the donor cellular material is removed, which minimizes immunological response in ADM recipients. The hADM retains native growth factors, collagen and elastin. Using hADM to support tissue expanders or implants for soft tissue reconstruction or to aid in wound healing, the matrix allows for rapid cellular proliferation and infiltration, integration of mesenchymal cells into the matrix and re-vascularization. This facilitates surgical reconstruction and protects against wound exposure and wound infection.