Definition

A cancer vaccine containing autologous dendritic cells (DCs) that are pulsed with mRNA encoding the tumor-associated antigens (TAAs) human telomerase reverse transcriptase (hTERT) and lysosome-associated membrane protein 1 (LAMP1), with potential immunostimulatory and antineoplastic activities. Upon administration, hTERT-LAMP mRNA-loaded autologous DC Vaccine GRNVAC1 may elicit a cytotoxic T-lymphocyte (CTL) response against tumor cells expressing hTERT and LAMP1. hTERT, the catalytic subunit of human telomerase, is upregulated in certain tumor cell types and plays an important role in tumor cell growth and survival. LAMP1, overexpressed on a variety of tumor cells, plays a key role in cell-cell adhesion and migration.