Single Biggest Cancer Dictionary in the World
What is ERK1/2 inhibitor LY3214996?
Pronunciation: /ərk wən tu ˌɪnˈhɪbətər laɪ θri ˈmɪljən, tu ˈhənərd ənd ˌfɔrˈtin ˈθaʊzənd, naɪn ˈhənərd ənd ninety-six*/
ERK1/2 inhibitor LY3214996
Definition
An orally available inhibitor of extracellular signal-regulated kinase (ERK) 1 and 2, with potential antineoplastic activity. Upon oral administration, LY3214996 inhibits both ERK 1 and 2, thereby preventing the activation of mitogen-activated protein kinase (MAPK)/ERK-mediated signal transduction pathways. This results in the inhibition of ERK-dependent tumor cell proliferation and survival. The MAPK/ERK pathway is often upregulated in a variety of tumor cell types and plays a key role in tumor cell proliferation, differentiation and survival.