Definition

An attenuated, cis-targeted interferon (IFN), with potential immunostimulating and antineoplastic activities. Upon administration, engineered IFN ORB-011 specifically targets, binds to and activates type 1 conventional dendritic cell (cDC1). As these are specific immune cells that specialize in presenting tumor antigens to, and activating, tumor cytotoxic CD8 T cells, ORB-011 may be able to stimulate a specific cytotoxic T-lymphocyte (CTL)-mediated anti-tumor immune response. ORB-011 is engineered in such a way as to minimize off-target IFN-based binding and thereby avoiding systemic toxicity.