Definition

An inhibitor of C-X-C chemokine receptor type 4 (CXCR4), with potential hematopoietic stem cell (HSC)-mobilizing activity. Upon administration, CXCR4 inhibitor GPC-100 targets and binds to CXCR4, thereby preventing the binding of stromal-cell derived factor-1 (SDF-1; C-X-C motif chemokine ligand 12; CXCL12) to CXCR4. This results in HSC release from the bone marrow and HSC movement into the peripheral circulation. The CXCL12/CXCR4 signaling pathway plays an important role in the migration and retention of HSC in the bone marrow.